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Anticancer potential of active alkaloids and synthetic analogs derived from marine invertebrates
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-09-06 , DOI: 10.1016/j.ejmech.2024.116850 Chunyan Cai 1 , Dejun Yang 1 , Yi Cao 1 , Zhaolei Peng 1 , Yulin Wang 1 , Jingjing Xi 1 , Chunmei Yan 1 , Xiaofang Li 1
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-09-06 , DOI: 10.1016/j.ejmech.2024.116850 Chunyan Cai 1 , Dejun Yang 1 , Yi Cao 1 , Zhaolei Peng 1 , Yulin Wang 1 , Jingjing Xi 1 , Chunmei Yan 1 , Xiaofang Li 1
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In recent years, the number of cancers has soared, becoming one of the leading causes of human death. At the same time, marine anticancer substances have been the focus of marine drug research. Marine alkaloids derived from marine invertebrates like sponges are an important class of secondary metabolites, which have good bioactivities of blocking the cancer cell cycle, inducing autophagy and apoptosis of cancer cells, inhibiting cancer cell invasion and proliferation. They show potential as anticancer drug candidates. Therefore, in this review, we focus on the detailed introduction of bioactive alkaloids and their synthetic analogs from marine invertebrates, such as 4-chloro fascapysin and other 41 kinds of marine alkaloids or marine alkaloid synthetic analogs. They have significant anticancer activities on breast cancer, cervical cancer, colorectal cancer, prostate cancer, lung cancer, liver cancer, and so on. It provides new candidate compounds for anticancer drug research and provides a reference basis for marine drug resources research.
中文翻译：
来自海洋无脊椎动物的活性生物碱和合成类似物的抗癌潜力
近年来，癌症数量激增，成为人类死亡的主要原因之一。同时，海洋抗癌物质一直是海洋药物研究的重点。海绵等来源于海洋无脊椎动物的海洋生物碱是一类重要的次生代谢产物，具有良好的阻断癌细胞周期、诱导癌细胞自噬和凋亡、抑制癌细胞侵袭和增殖的生物活性。它们显示出作为抗癌候选药物的潜力。因此，本文重点介绍了海洋无脊椎动物生物活性生物碱及其合成类似物的详细介绍，如 4-氯 fascapysin 等 41 种海洋生物碱或海洋生物碱合成类似物。它们对乳腺癌、宫颈癌、结直肠癌、前列腺癌、肺癌、肝癌等具有显着的抗癌活性。为抗癌药物研究提供了新的候选化合物，为海洋药物资源研究提供了参考依据。
更新日期：2024-09-06
中文翻译：
来自海洋无脊椎动物的活性生物碱和合成类似物的抗癌潜力
近年来，癌症数量激增，成为人类死亡的主要原因之一。同时，海洋抗癌物质一直是海洋药物研究的重点。海绵等来源于海洋无脊椎动物的海洋生物碱是一类重要的次生代谢产物，具有良好的阻断癌细胞周期、诱导癌细胞自噬和凋亡、抑制癌细胞侵袭和增殖的生物活性。它们显示出作为抗癌候选药物的潜力。因此，本文重点介绍了海洋无脊椎动物生物活性生物碱及其合成类似物的详细介绍，如 4-氯 fascapysin 等 41 种海洋生物碱或海洋生物碱合成类似物。它们对乳腺癌、宫颈癌、结直肠癌、前列腺癌、肺癌、肝癌等具有显着的抗癌活性。为抗癌药物研究提供了新的候选化合物，为海洋药物资源研究提供了参考依据。
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