Putative epithelial–mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations,Annals of the New York Academy of Sciences

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Putative epithelial–mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2024-09-13 , DOI: 10.1111/nyas.15210
Ryan T Kim ₁ , Jessica L Whited _{1,

2,

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Affiliation

Previous studies have implicated epithelial–mesenchymal transition (EMT) in salamander limb regeneration. In this review, we describe putative roles for EMT during each stage of limb regeneration in axolotls and other salamanders. We hypothesize that EMT and EMT-like gene expression programs may regulate three main cellular processes during limb regeneration: (1) keratinocyte migration during wound closure; (2) transient invasion of the stump by epithelial cells undergoing EMT; and (3) use of EMT-like programs by non-epithelial blastemal progenitor cells to escape the confines of their niches. Finally, we propose nontraditional roles for EMT during limb regeneration that warrant further investigation, including alternative EMT regulators, stem cell activation, and fibrosis induced by aberrant EMT.

中文翻译：

蝾螈肢体再生过程中推定的上皮-间充质转化：当前观点和未来研究

以前的研究表明上皮-间充质转化（EMT）与蝾螈肢体再生有关。在这篇综述中，我们描述了 EMT 在蝾螈和其他蝾螈肢体再生的每个阶段的推定作用。我们假设 EMT 和 EMT 样基因表达程序可能调节肢体再生过程中的三个主要细胞过程：（1）伤口闭合过程中的角质形成细胞迁移;（2）接受 EMT 的上皮细胞短暂侵袭残端;（3）非上皮胚芽生祖细胞使用 EMT 样程序来逃脱其生态位的限制。最后，我们提出了 EMT 在肢体再生过程中的非传统作用，值得进一步研究，包括替代 EMT 调节因子、干细胞激活和异常 EMT 诱导的纤维化。

更新日期：2024-09-13

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