Positronium image of the human brain in vivo,Science Advances

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Positronium image of the human brain in vivo
Science Advances ( IF 11.7 ) Pub Date : 2024-09-13 , DOI: 10.1126/sciadv.adp2840
Paweł Moskal _{1,

2} , Jakub Baran _{1,

2} , Steven Bass _{1,

2,

3} , Jarosław Choiński ₄ , Neha Chug _{1,

2} , Catalina Curceanu ₅ , Eryk Czerwiński _{1,

2} , Meysam Dadgar _{1,

2} , Manish Das _{1,

2} , Kamil Dulski _{1,

2} , Kavya V Eliyan _{1,

2} , Katarzyna Fronczewska ₆ , Aleksander Gajos _{1,

2} , Krzysztof Kacprzak _{1,

2} , Marcin Kajetanowicz _{1,

2} , Tevfik Kaplanoglu _{1,

2} , Łukasz Kapłon _{1,

2} , Konrad Klimaszewski ₇ , Małgorzata Kobylecka ₆ , Grzegorz Korcyl _{1,

2} , Tomasz Kozik _{1,

2} , Wojciech Krzemień _{1,

2,

8} , Karol Kubat _{1,

2} , Deepak Kumar _{1,

2} , Jolanta Kunikowska ₆ , Joanna Mączewska ₆ , Wojciech Migdał _{1,

2} , Gabriel Moskal _{2,

9} , Wiktor Mryka _{1,

2} , Szymon Niedźwiecki _{1,

2} , Szymon Parzych _{1,

2} , Elena P Del Rio _{1,

2} , Lech Raczyński ₇ , Sushil Sharma _{1,

2} , Shivani Shivani _{1,

2} , Roman Y Shopa ₇ , Michał Silarski _{1,

2} , Magdalena Skurzok _{1,

2} , Faranak Tayefi _{1,

2} , Keyvan T Ardebili _{1,

2} , Pooja Tanty _{1,

2} , Wojciech Wiślicki ₇ , Leszek Królicki ₆ , Ewa Ł Stępień _{1,

2}

Affiliation

Positronium is abundantly produced within the molecular voids of a patient’s body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.

中文翻译：

体内人脑的正电子图像

在正电子发射断层扫描（PET）期间，患者体内的分子空隙中大量产生正电子。它的特性动态地响应组织的亚分子结构和氧分压。目前的 PET 系统仅记录两个湮灭光子，无法提供有关正电子寿命的信息。本研究通过使用专用的 Jagiellonian PET 系统，为胶质母细胞瘤脑肿瘤患者展示了人类正电子寿命的体内图像，该系统能够同时检测放射性核素发射的湮灭光子和瞬发伽马。提示 γ 提供有关正电子形成时间的信息。正电子湮灭产生的光子用于重建其衰变的地点和时间。在所介绍的案例研究中，胶质母细胞瘤细胞中确定的正电子和正电子寿命短于唾液腺和健康脑组织中的正电子和正电子寿命，这表明正电子成像可用于体内疾病诊断。

更新日期：2024-09-13

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