Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial,The Lancet Respiratory Medicine

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Mirtazapine to alleviate severe breathlessness in patients with COPD or interstitial lung diseases (BETTER-B): an international, multicentre, double-blind, randomised, placebo-controlled, phase 3 mixed-method trial
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2024-09-09 , DOI: 10.1016/s2213-2600(24)00187-5
Irene J Higginson ₁ , Sarah T Brown ₂ , Adejoke O Oluyase ₃ , Peter May ₄ , Matthew Maddocks ₃ , Massimo Costantini ₃ , Sabrina Bajwah ₁ , Charles Normand ₄ , Claudia Bausewein ₅ , Steffen T Simon ₆ , Karen Ryan ₇ , David C Currow ₈ , Miriam J Johnson ₉ , Simon P Hart ₁₀ , Hannah Mather ₂ , Malgorzata Krajnik ₁₁ , Silvia Tanzi ₁₂ , Luca Ghirotto ₁₂ , Charlotte E Bolton ₁₃ , Piotr Janowiak ₁₄ , Elena Turola ₁₂ , Caroline J Jolley ₁₅ , Geraldine Murden ₂ , Andrew Wilcock ₁₆ , Bobbie Farsides ₁₇ , Julia M Brown ₂ ,

Affiliation

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; King's College Hospital NHS Foundation Trust, London, UK.
Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.
Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK; School of Medicine, Trinity College Dublin, Dublin, Ireland.
LMU University Hospital, Department for Palliative Medicine, Ludwig-Maximilians-University Muenchen, Munich, Germany.
University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine and Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany.
University College Dublin and Mater Misericordiae University Hospital Dublin, Dublin, Ireland.
Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Wolfson Palliative Care Research Centre, Hull York Medical School, The University of Hull, Hull, UK.
Respiratory Research Group, Hull York Medical School, The University of Hull, Hull, UK.
Department of Palliative Care, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
NIHR Nottingham Biomedical Research Centre, Translational Medical Sciences, School of Medicine, The University of Nottingham, Nottingham, UK.
Division of Pulmonology, Gdanski Uniwersytet Medyczny, Gdańsk, Poland.
King's College Hospital NHS Foundation Trust, London, UK; Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, King's College London, London, UK.
Department of Clinical Oncology, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Brighton and Sussex Medical School, University of Sussex, Brighton, UK.

Breathlessness frequently becomes severe among people with respiratory disease. Mirtazapine, a widely used antidepressant, has shown promise in the modulation of respiratory sensation and the response to it, as well as reducing feelings of panic, which often accompanies breathlessness. We aimed to determine the effectiveness of mirtazapine to alleviate severe persisting breathlessness.

中文翻译：

米氮平缓解 COPD 或间质性肺病患者的严重呼吸困难（BETTER-B）：一项国际、多中心、双盲、随机、安慰剂对照、3 期混合方法试验

呼吸系统疾病患者呼吸困难经常变得严重。米氮平是一种广泛使用的抗抑郁药，在调节呼吸感觉和对呼吸感觉的反应以及减少经常伴随着呼吸困难的恐慌感方面显示出前景。我们旨在确定米氮平缓解严重持续呼吸困难的有效性。

更新日期：2024-09-09

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