The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators,European Journal of Medicinal Chemistry

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The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-09-07 , DOI: 10.1016/j.ejmech.2024.116845
Angela Lamberti ₁ , Marta Serafini ₂ , Silvio Aprile ₂ , Irene Preet Bhela ₂ , Georgia Goutsiou ₂ , Emanuela Pessolano ₂ , Gregorio Fernandez-Ballester ₁ , Antonio Ferrer-Montiel ₁ , Rita Maria Concetta Di Martino ₂ , Asia Fernandez-Carvajal ₁ , Tracey Pirali ₂

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A growing body of evidence points to the existence of a crosstalk between the endovanilloid (EV)- and the endocannabinoid (EC) systems, leading to the concept of a single system based on a shared set of endogenous ligands and regulation mechanisms. The EV/EC system encompasses the ion channel TRPV1, the G protein coupled receptors CB1 and CB2, their endogenous ligands and the enzymes for biosynthesis and inactivation. Disorders in which the EV/EC interaction is involved are inflammation, pain, neurodegenerative diseases and disorders of bones and skin.

中文翻译：

多组分 Passerini 反应作为获得结构、活性和特性多样性的手段：软硬香草素/大麻素调节剂

越来越多的证据表明，内源性香草素（EV）和内源性大麻素（EC）系统之间存在串扰，导致了基于一组共享的内源性配体和调节机制的单一系统的概念。EV/EC 系统包括离子通道 TRPV1、G 蛋白偶联受体 CB1 和 CB2、它们的内源性配体以及用于生物合成和灭活的酶。涉及 EV/EC 相互作用的疾病包括炎症、疼痛、神经退行性疾病以及骨骼和皮肤疾病。

更新日期：2024-09-07

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