Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential,Annals of the New York Academy of Sciences

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Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2024-09-13 , DOI: 10.1111/nyas.15213
Edouard G Mills _{1,

2} , Ali Abbara _{1,

2} , Waljit S Dhillo _{1,

2} , Alexander N Comninos _{1,

2,

3}

Affiliation

The neuropeptide kisspeptin and its cognate receptor have been extensively studied in reproductive physiology, with diverse and well-established functions, including as an upstream regulator of pubertal onset, reproductive hormone secretion, and sexual behavior. Besides classical reproduction, both kisspeptin and its receptor are extensively expressed in bone-resorbing osteoclasts and bone-forming osteoblasts, which putatively permits direct bone effects. Accordingly, this sets the scene for recent compelling findings derived from in vitro experiments through to in vivo and clinical studies revealing prominent regulatory interactions for kisspeptin signaling in bone metabolism, as well as certain oncological aspects of bone metabolism. Herein, we comprehensively examine the experimental evidence obtained to date supporting the interaction between kisspeptin and bone. A comprehensive understanding of this emerging facet of kisspeptin biology is fundamental to exploiting the future therapeutic potential of kisspeptin-based medicines as a novel strategy for treating bone-related disorders.

中文翻译：

kisspeptin 与骨骼之间的相互作用：细胞机制、临床证据和未来潜力

神经肽 kisspeptin 及其同源受体已在生殖生理学中得到广泛研究，具有多种且公认的功能，包括作为青春期开始、生殖激素分泌和性行为的上游调节因子。除了经典生殖外，kisspeptin 及其受体都在骨吸收破骨细胞和成骨成骨细胞中广泛表达，这推测允许直接的骨效应。因此，这为最近从体外实验到体内和临床研究得出的令人信服的发现奠定了基础，这些发现揭示了 kisspeptin 信号转导在骨代谢中的重要调节相互作用，以及骨代谢的某些肿瘤学方面。在此，我们全面研究了迄今为止获得的实验证据，支持 kisspeptin 与骨骼之间的相互作用。全面了解 kisspeptin 生物学的这一新兴方面对于开发基于 kisspeptin 的药物作为治疗骨骼相关疾病的新策略的未来治疗潜力至关重要。

更新日期：2024-09-13

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