Surgical incision infection is the most common postoperative complication that poses a serious threat to human health. In this work, the iron gallate (GA-Fe) modified hyaluronic acid microspheres (GFe@HAMSs) multifunctional dressings with antibacterial activity, biodegradability, and the ability to promote tissue regeneration for infectious wound healing are prepared via the bonding engineering between bioactive iron ions and ligands from both polyphenol (i.e. gallic acid, GA) and HAMSs matrix. In our strategy, the Fe-HAMS interaction is first constructed, leading to the shrinkage of iron-doped HAMSs (Fe@HAMSs). Then, the addition of GA further tunes the metal-matrix bonding by introducing the competitive equilibrium between Fe-HAMS and Fe-GA chelation, leading to the volume expansion of GFe@HAMSs. The introduction of iron ions can effectively shorten the inflammatory response and reverse the iron-deficient microenvironment, thereby transforming the wound microenvironment into one conducive to tissue regeneration. Benefitting from these bioactive effects of iron ions and the photothermal antibacterial activity of GA-Fe, the GFe@HAMSs significantly accelerate the wound healing process for rat skin-infected wounds by inhibiting the inflammatory response and macrophage polarization and promoting angiogenesis and tissue remodeling. The GFe@HAMSs proposed in this work not only provide a biomaterial for infectious wound healing but also offer a new strategy for designing multifunctional dressing.

中文翻译：

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通过金属配体键合工程制备多功能微球敷料，用于感染性伤口愈合


手术切口感染是最常见的术后并发症，对人类健康构成严重威胁。在这项工作中，通过生物活性铁离子与来自多酚（即没食子酸，GA）和 HAMSs 基质的配体之间的键合工程制备了具有抗菌活性、生物降解性和促进组织再生以实现感染性伤口愈合的能力的没食子酸铁 （GA-Fe） 修饰的透明质酸微球 （GFe@HAMSs） 多功能敷料。在我们的策略中，首先构建了 Fe-HAMS 相互作用，导致掺铁 HAMS （Fe@HAMSs） 的收缩。然后，GA 的添加通过在 Fe-HAMS 和 Fe-GA 螯合之间引入竞争平衡来进一步调节金属基体键合，从而导致 GFe@HAMSs 的体积膨胀。铁离子的引入可以有效缩短炎症反应并逆转缺铁微环境，从而将伤口微环境转变为有利于组织再生的微环境。得益于铁离子的这些生物活性作用和 GA-Fe 的光热抗菌活性，该GFe@HAMSs通过抑制炎症反应和巨噬细胞极化以及促进血管生成和组织重塑，显着加速大鼠皮肤感染伤口的伤口愈合过程。这项工作提出的GFe@HAMSs不仅为感染性伤口愈合提供了一种生物材料，而且为设计多功能敷料提供了一种新的策略。