<br>腺苷 A1 受体在外源性酮补充剂引发的抗癫痫作用中的假定作用,International Journal of Molecular Sciences

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腺苷 A1 受体在外源性酮补充剂引发的抗癫痫作用中的假定作用
International Journal of Molecular Sciences ( IF 4.9 ) Pub Date : 2024-09-12 , DOI: 10.3390/ijms25189869
Zsolt Kovács ₁ , Enikő Rauch _{1,

2} , Dominic P. D’Agostino _{3,

4,

5} , Csilla Ari _{3,

6}

Affiliation

大约 30% 的癫痫患者对药物耐药。迫切需要阐明不同类型癫痫的确切病理生理学以及抗癫痫药物和代谢疗法的作用机制，以便更有效、更安全地治疗患者。例如，已经证明，外源性酮补充剂（EKS）产生的治疗性酮症作为一种代谢疗法，可以减少动物模型和人类的癫痫活动，但其确切的作用机制尚不清楚。然而，研究表明，治疗性酮症等可以增加腺苷水平，这可能会增强大脑中 A1 腺苷受体 (A1R) 的活性。此前也已证明，腺苷通过 A1R 在不同的癫痫模型中具有抗癫痫作用。因此，有可能 (i) 通过施用 EKS 产生的治疗性酮症可能通过增加腺苷水平和 A1R 活性等机制发挥其抗癫痫作用，并且 (ii) A1R 活性增强可能是必要的EKS 给药产生的酮症引起的抗癫痫机制。此外，EKS 可以引发并维持酮症，而没有严重的副作用。这些结果还表明，EKS 产生的酮症的治疗应用可能是治疗不同类型癫痫的一个有希望的机会。在这篇文献综述中，我们特别关注 A1Rs 在 EKS 诱导的酮症的抗癫痫作用中的假定作用。

"点击查看英文标题和摘要"

Putative Role of Adenosine A1 Receptors in Exogenous Ketone Supplements-Evoked Anti-Epileptic Effect

Approximately 30% of patients with epilepsy are drug-refractory. There is an urgent need to elucidate the exact pathophysiology of different types of epilepsies and the mechanisms of action of both antiseizure medication and metabolic therapies to treat patients more effectively and safely. For example, it has been demonstrated that exogenous ketone supplement (EKS)-generated therapeutic ketosis, as a metabolic therapy, may decrease epileptic activity in both animal models and humans, but its exact mechanism of action is unknown. However, it was demonstrated that therapeutic ketosis, among others, can increase adenosine level, which may enhance activity of A1 adenosine receptors (A1Rs) in the brain. It has also been demonstrated previously that adenosine has anti-epileptic effect through A1Rs in different models of epilepsies. Thus, it is possible that (i) therapeutic ketosis generated by the administration of EKSs may exert its anti-epileptic effect through, among other mechanisms, increased adenosine level and A1R activity and that (ii) the enhanced activity of A1Rs may be a necessary anti-epileptic mechanism evoked by EKS administration-generated ketosis. Moreover, EKSs can evoke and maintain ketosis without severe side effects. These results also suggest that the therapeutic application of EKS-generated ketosis may be a promising opportunity to treat different types of epilepsies. In this literature review, we specifically focus on the putative role of A1Rs in the anti-epileptic effect of EKS-induced ketosis.

更新日期：2024-09-13

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