We reveal that lipid turnover in the myelin sheath generates a fatty acid pool in oligodendrocytes that can contribute to the energy balance of white matter tracts. We also demonstrate that when glucose levels are limiting, fatty acid metabolism can support glial cell survival and the basic functional integrity of myelinated axons.

中文翻译：

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髓磷脂脂质代谢可为饥饿的轴突提供能量


我们发现髓鞘中的脂质周转会在少突胶质细胞中产生脂肪酸池，这有助于白质束的能量平衡。我们还证明，当葡萄糖水平受到限制时，脂肪酸代谢可以支持神经胶质细胞的存活和有髓轴突的基本功能完整性。