We examined brain and cognitive reserve related to bilingualism in older adults with, or at-risk for, Alzheimer's disease (AD) from the Canadian Consortium on Neurodegeneration in Aging and the Quebec Consortium for the Early Identification of Alzheimer's Disease. We used surface-based morphometry methods to measure cortical thickness and volume of language-related and AD-related brain regions. We did not observe evidence of brain reserve in language-related regions. However, reduced hippocampal volume was observed for monolingual, but not bilingual, older adults with AD. Thus, bilingualism is hypothesized to contribute to reserve in the form of brain maintenance in the context of AD.

我们检查了加拿大老年神经退行性疾病联盟和魁北克阿尔茨海默病早期识别联盟的患有阿尔茨海默病 (AD) 或有患阿尔茨海默病 (AD) 风险的老年人与双语相关的大脑和认知储备。我们使用基于表面的形态测量方法来测量与语言相关和 AD 相关的大脑区域的皮质厚度和体积。我们没有观察到语言相关区域的大脑储备的证据。然而，观察到单语而非双语老年 AD 患者的海马体积减少。因此，假设双语能力有助于在 AD 背景下以维持大脑的形式进行储备。