The distinct anatomic environment in which adipose tissues arise during organogenesis is a principle determinant of their adult expansion capacity. Metabolic disease results from a deficiency in hyperplastic adipose expansion within the dermal/subcutaneous depot; thus, understanding the embryonic origins of dermal adipose is imperative. Using single-cell transcriptomics throughout murine embryogenesis, we characterized cell populations, including Bcl11b⁺ cells, that regulate the development of dermal white adipose tissue (dWAT). We discovered that BCL11b expression modulates the Wnt signaling microenvironment to enable adipogenic differentiation in the dermal compartment. Subcutaneous and visceral adipose arises from a distinct population of Nefl⁺ cells during embryonic organogenesis, whereas Pi16⁺/Dpp4⁺ fibroadipogenic progenitors support obesity-stimulated hypertrophic expansion in the adult. Together, these results highlight the unique regulatory pathways used by anatomically distinct adipose depots, with important implications for human metabolic disease.

中文翻译：

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BCL11b 对真皮脂肪组织的发育调节


脂肪组织在器官发生过程中产生的独特解剖环境是其成人扩张能力的主要决定因素。代谢性疾病是由于真皮/皮下贮库内增生性脂肪扩张不足引起的;因此，了解真皮脂肪的胚胎起源势在必行。在整个小鼠胚胎发生过程中使用单细胞转录组学，我们表征了调节真皮白色脂肪组织 （dWAT） 发育的细胞群，包括 Bcl11b ⁺ 细胞。我们发现 BCL11b 表达调节 Wnt 信号微环境，从而在真皮区室中实现成脂分化。皮下和内脏脂肪起源于胚胎器官发生过程中不同的 Nefl⁺ 细胞群，而 Pi16⁺/Dpp4⁺ 成纤维脂肪祖细胞支持成人肥胖刺激的肥大性扩增。总之，这些结果突出了解剖学上不同的脂肪库使用的独特调节途径，对人类代谢疾病具有重要意义。