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Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-12 , DOI: 10.1021/acs.jafc.4c03367 Yuting Ma 1 , Haifeng Wang 1 , Xiao Hu 1 , Hong Zou 2 , Tongyi Xu 1 , Zhigao Wang 1 , Xingrong Ju 1 , Rong He 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-12 , DOI: 10.1021/acs.jafc.4c03367 Yuting Ma 1 , Haifeng Wang 1 , Xiao Hu 1 , Hong Zou 2 , Tongyi Xu 1 , Zhigao Wang 1 , Xingrong Ju 1 , Rong He 1
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Royal jelly (RJ) is a natural food product with nutritional value and anticancer activity. However, their effects on gastric cancer are unclear. Here, we show that treatment with 5–320 μg/mL of RJ, ethanol extract (RJEE), and protein hydrolyzate (RJPH) decreased the viability of MKN-28 gastric cancer cells, with a half-maximal inhibitory concentration of 123.22 μg/mL for RJEE. RJ, RJEE, and RJPH increase the lactate dehydrogenase release rate and change the morphology of the cells, resulting in cell shrinkage, nucleoplasm condensation, and the formation of apoptotic bodies. RJ and its functional components stagnated the cell cycle in the G0/G1 phase, accompanied by the accumulation of reactive oxygen species, decreased mitochondrial membrane potential, and increased expression levels of p53 and p21 proteins, caspase-3 activation, and apoptosis. Therefore, RJ, RJEE, and RJPH have potential inhibitory effects on the proliferation of gastric cancer cells.
中文翻译：
蜂王浆及其功能成分对MKN-28胃癌细胞增殖的抑制作用
蜂王浆（RJ）是一种具有营养价值和抗癌活性的天然食品。然而，它们对胃癌的影响尚不清楚。在这里，我们发现用 5–320 μg/mL 的 RJ、乙醇提取物 (RJEE) 和蛋白水解物 (RJPH) 处理可降低 MKN-28 胃癌细胞的活力，半数最大抑制浓度为 123.22 μg/ RJEE 的毫升数。 RJ、RJEE和RJPH增加乳酸脱氢酶的释放速率并改变细胞的形态，导致细胞皱缩、核质浓缩和凋亡小体的形成。 RJ及其功能成分使细胞周期停滞在G0/G1期，伴随着活性氧的积累、线粒体膜电位降低、p53和p21蛋白表达水平升高、caspase-3激活和细胞凋亡。因此，RJ、RJEE和RJPH对胃癌细胞的增殖具有潜在的抑制作用。
更新日期：2024-09-12
中文翻译：
蜂王浆及其功能成分对MKN-28胃癌细胞增殖的抑制作用
蜂王浆（RJ）是一种具有营养价值和抗癌活性的天然食品。然而，它们对胃癌的影响尚不清楚。在这里，我们发现用 5–320 μg/mL 的 RJ、乙醇提取物 (RJEE) 和蛋白水解物 (RJPH) 处理可降低 MKN-28 胃癌细胞的活力，半数最大抑制浓度为 123.22 μg/ RJEE 的毫升数。 RJ、RJEE和RJPH增加乳酸脱氢酶的释放速率并改变细胞的形态，导致细胞皱缩、核质浓缩和凋亡小体的形成。 RJ及其功能成分使细胞周期停滞在G0/G1期，伴随着活性氧的积累、线粒体膜电位降低、p53和p21蛋白表达水平升高、caspase-3激活和细胞凋亡。因此，RJ、RJEE和RJPH对胃癌细胞的增殖具有潜在的抑制作用。
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