Template-assisted Flexible-to-rigid Transition of Peptides in Head-to-tail Self-polymerization Enables Sequence-controllable and Post-modifiable Peptide Nanofibers,Angewandte Chemie International Edition

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Template-assisted Flexible-to-rigid Transition of Peptides in Head-to-tail Self-polymerization Enables Sequence-controllable and Post-modifiable Peptide Nanofibers
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-12 , DOI: 10.1002/anie.202415809
Tianzi Chen ₁ , Yin Liu ₁ , Zhanshan Gao ₁ , Yue Gao ₁ , Haijin Chen ₁ , Haonan Ye ₁ , Qiuhao Luo ₁ , Kefeng Wang ₁ , Dongdong Wu ₂

Affiliation

Series-connected peptide nanofibers (SCPNs) were synthesized using a template-assisted strategy to trigger the flexible-to-rigid conformational transition of peptides, thereby avoiding backbite effects and enabling continuous intermolecular reactions during the self-polymerization of peptides. SCPNs should represent a new category of peptide-based nanofibers with numerous intrinsic outstanding performances and great potential.

中文翻译：

在头尾自聚合中肽的模板辅助柔性到刚性转变可实现序列可控和可后修饰的肽纳米纤维

使用模板辅助策略合成串联肽纳米纤维（SCPN）以触发肽的柔性到刚性构象转变，从而避免反咬效应并在肽自聚合过程中实现连续的分子间反应。SCPN 应该代表一种新的基于肽的纳米纤维类别，具有许多内在的出色性能和巨大的潜力。

更新日期：2024-09-12

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