当前位置:
X-MOL 学术
›
Alzheimers Dement.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-09-11 , DOI: 10.1002/alz.14190 Narayan Datt Soni 1 , Anshuman Swain 1, 2 , Halvor Juul 1 , Quy Cao 3 , Mohammad Haris 1 , David A Wolk 4, 5 , Virginia M-Y Lee 5, 6 , John A Detre 7 , Ravi Prakash Reddy Nanga 1 , Ravinder Reddy 1
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2024-09-11 , DOI: 10.1002/alz.14190 Narayan Datt Soni 1 , Anshuman Swain 1, 2 , Halvor Juul 1 , Quy Cao 3 , Mohammad Haris 1 , David A Wolk 4, 5 , Virginia M-Y Lee 5, 6 , John A Detre 7 , Ravi Prakash Reddy Nanga 1 , Ravinder Reddy 1
Affiliation
Regional glucose hypometabolism resulting in glutamate loss has been shown as one of the characteristics of Alzheimer's disease (AD). Because the impact of AD varies between the sexes, we utilized glutamate-weighted chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) for high-resolution spatial mapping of cerebral glutamate and investigated subregional changes in a sex-specific manner.
中文翻译:
使用 GluCEST MRI 检测早期阿尔茨海默病小鼠模型中海马亚区的性别特异性谷氨酸变化
导致谷氨酸丢失的区域葡萄糖代谢减退已被证明是阿尔茨海默病 (AD) 的特征之一。由于 AD 的影响因性别而异,我们利用谷氨酸加权化学交换饱和转移 (GluCEST) 磁共振成像 (MRI) 对脑谷氨酸进行高分辨率空间映射,并以性别特异性方式研究亚区域变化。
更新日期:2024-09-11
中文翻译:
使用 GluCEST MRI 检测早期阿尔茨海默病小鼠模型中海马亚区的性别特异性谷氨酸变化
导致谷氨酸丢失的区域葡萄糖代谢减退已被证明是阿尔茨海默病 (AD) 的特征之一。由于 AD 的影响因性别而异,我们利用谷氨酸加权化学交换饱和转移 (GluCEST) 磁共振成像 (MRI) 对脑谷氨酸进行高分辨率空间映射,并以性别特异性方式研究亚区域变化。