γδT cells represent a group of immune cells that are understudied but whose utility has been recognized for cancer immunotherapy purposes. Recent studies have highlighted a critical role for these cells in tumor initiation, growth, and metastasis and revealed an increasingly complex biology of γδT cell subsets that is context and tissue specific. We discuss here how γδT cell subsets are regulated, their interaction with cancer and other immune cells, and the implications from these latest discoveries for people with cancer.

中文翻译：

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从后台到聚光灯下：γδT 细胞在癌症中的应用


γδT 细胞代表一组研究不足但其效用已得到认可用于癌症免疫治疗目的的免疫细胞。最近的研究强调了这些细胞在肿瘤发生、生长和转移中的关键作用，并揭示了 γδT 细胞亚群的生物学特性越来越复杂，这是背景和组织特异性的。我们在这里讨论 γδT 细胞亚群是如何被调节的，它们与癌症和其他免疫细胞的相互作用，以及这些最新发现对癌症患者的影响。