In this issue of Chem, Yamaguchi and coworkers introduce an exciting strategy for the deacylative cross-coupling of aromatic ketones. Aromatic ketones are first converted into aromatic esters via sequential Claisen and regioselective retro-Claisen condensation. The esters then undergo transition-metal-catalyzed decarbonylative cross-coupling reactions with various nucleophiles affording C–C and C–heteroatom bond formation products.

中文翻译：

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在多功能交叉偶联反应中促进芳香酮作为芳基亲电子试剂


在本期《Chem》中，Yamaguchi 和同事介绍了一种令人兴奋的芳香酮脱酰交叉偶联策略。芳香酮首先通过顺序克莱森和区域选择性逆克莱森缩合转化为芳香酯。然后酯与各种亲核试剂发生过渡金属催化的脱羰交叉偶联反应，形成 C-C 和 C-杂原子键形成产物。