Ruthenium(II)-Catalyzed Remote C–H Alkylation of Arenes Using Diverse N-Directing Groups through Aziridine Ring Opening,Organic Letters

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Ruthenium(II)-Catalyzed Remote C–H Alkylation of Arenes Using Diverse N-Directing Groups through Aziridine Ring Opening
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-12 , DOI: 10.1021/acs.orglett.4c02254
Hongyan Lan ₁ , Yingzhen Liu ₁ , Lutz Ackermann ₂ , Lanfen Wang ₁ , Dingyi Wang ₁

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An efficient approach for the remote C–H alkylation of arenes, employing a variety of N-directing groups is described. This method facilitates the straightforward synthesis of valuable phenylethylamine derivatives by exclusively cleaving the benzylic C–N bond in aziridines. Furthermore, these products can easily remove the protecting groups, resulting in a variety of meta-substituted compounds, such as amines and ketones, which hold significance in synthetic chemistry.

中文翻译：

钌 (II) 催化芳烃通过氮丙啶开环使用多种 N 基团进行远程 C–H 烷基化

描述了一种使用各种 N 导向基团进行芳烃远程 C-H 烷基化的有效方法。该方法通过专门裂解氮丙啶中的苄基 C-N 键，促进了有价值的苯乙胺衍生物的直接合成。此外，这些产品可以很容易地去除保护基团，产生各种间位取代的化合物，例如胺和酮，这在合成化学中具有重要意义。

更新日期：2024-09-12

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