Organocatalytic Deoxygenative [3+2] Cycloaddition of N-Hydroxyamides with Alkynes to Access Isoxazoles,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Organocatalytic Deoxygenative [3+2] Cycloaddition of N-Hydroxyamides with Alkynes to Access Isoxazoles
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-12 , DOI: 10.1021/acs.orglett.4c02852
Haixiang Wang ₁ , Yan Sun ₁ , Wentong Liu ₁ , Liliang Huang ₁ , Huangdi Feng ₁

Affiliation

Although the transition-metal-catalyzed [3+2] cycloadditions to access isoxazoles have been described well, organocatalytic methods remain underdeveloped. Herein, we report the use of an organophosphine catalyst for the preparation of a series of isoxazoles with exceptional regioselectivity via the [3+2] cycloaddition of N-hydroxyamides and alkynes. The scope of this organocatalytic transformation is broad, tolerating numerous functional groups and proceeding uniformly in an environmentally friendly, simple, and efficient manner.

中文翻译：

N-羟基酰胺与炔烃的有机催化脱氧[3+2]环加成反应生成异恶唑

尽管过渡金属催化的[3+2]环加成反应获得异恶唑已经得到很好的描述，但有机催化方法仍然不发达。在此，我们报道了使用有机膦催化剂通过N-羟基酰胺和炔烃的[3+2]环加成制备一系列具有优异区域选择性的异恶唑。这种有机催化转化的范围很广，可以容纳多种官能团，并且以环境友好、简单、高效的方式均匀地进行。

更新日期：2024-09-12

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南