Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study,Leukemia

当前位置： X-MOL 学术 › Leukemia › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study
Leukemia ( IF 12.8 ) Pub Date : 2024-09-12 , DOI: 10.1038/s41375-024-02402-8
Florence Rabian ₁ , Sylvie Chevret ₂ , Bérengère Gruson ₃ , Sylvain Thépot ₄ , Anouk Walter-Petrich ₂ , Thorsten Braun ₅ , Norbert Vey ₆ , José Miguel Torregrosa-Diaz ₇ , Pierre Peterlin ₈ , Andrea Toma ₉ , Maud D'Aveni ₁₀ , Jacques Delaunay ₁₁ , Laurence Legros ₁₂ , Nathalie Droin ₁₃ , Fatiha Chermat ₁₄ , Daniel Lusina ₁₅ , Lionel Adès _{1,

16} , Rosa Sapena ₁₄ , Eric Solary ₁₃ , Pierre Fenaux _{1,

16} , Raphael Itzykson _{1,

16}

Affiliation

Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.
SBIM, APHP, Hôpital Saint-Louis, INSERM, UMR-1153, ECSTRRA Team, Paris, France.
Hematology Department CHU Amiens, Amiens, France.
Hematology Department CHU Angers, Université Angers, Angers, France.
Hematology Department, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
Hematology Department, Institut Paoli-Calmettes, Marseille, France.
Service d'Hématologie Oncologique et Thérapie Cellulaire, CIC INSERM 1402, University Hospital of Poitiers, Poitiers, France.
Hematology Department CHU Nantes, Université Nantes, Nantes, France.
Geriatric Hematology Unit, Hopitaux Universitaires Henri Mondor, Assistance Publique-Hopitaux-de-Paris, Draveil, France.
Hematology Department, University Hospital of Nancy, Nancy, France.
Hematology Unit, Hôpital Privé Le Confluent, Nantes, France.
Department of Hematology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre, France.
Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.
Groupe Francophone des Myélodysplasies, F-75010, Paris, France.
Hematology Laboratory, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010, Paris, France.

Severe thrombocytopenia (<50 ×10⁹/L) occurs in 10–30% of Chronic Myelomonocytic Leukemias (CMML) and leads to significant mortality through increased risk of bleeding and disease progression [1]. Its management is ill codified [2].

The thrombopoietin receptor agonist Eltrombopag improves platelet counts in lower-risk myelodysplastic syndromes [3]. Its activity in CMML has been investigated in retrospective case series of up to eleven patients [4,5,6], or as part of a phase I MDS trial [7].

中文翻译：