The liver has a critical role in regulating host metabolism, immunity, detoxification, and homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic signaling pathways can lead to the onset of disease. The Wnt/β-catenin signaling pathway is an important regulator of liver homeostasis and function. Throughout life, hepatic Wnt/β-catenin signaling contributes to liver development and growth, metabolic zonation, and regeneration. Extensive research has demonstrated that aberrant Wnt/β-catenin signaling drives liver pathologies, including cancers, steatohepatitis, and cholestasis. In this review, we discuss the Wnt/β-catenin pathway as it pertains to liver function and how disruptions in this pathway contribute to the onset and progression of liver diseases. Further, we discuss ongoing research that targets the Wnt/β-catenin pathway for the treatment of liver pathologies.

中文翻译：

---

肝脏病理生物学中的 Wnt/β-catenin 信号转导


肝脏在调节宿主代谢、免疫、解毒和体内平衡方面起着关键作用。适当的肝功能对宿主健康至关重要，肝脏信号通路失调会导致疾病的发作。Wnt/β-catenin 信号通路是肝脏稳态和功能的重要调节因子。在整个生命过程中，肝脏 Wnt/β-catenin 信号转导有助于肝脏发育和生长、代谢分区和再生。广泛的研究表明，异常的 Wnt/β-catenin 信号转导会驱动肝脏病变，包括癌症、脂肪性肝炎和胆汁淤积。在这篇综述中，我们讨论了与肝功能相关的 Wnt/β-catenin 通路，以及该通路的破坏如何导致肝病的发生和发展。此外，我们讨论了正在进行的针对 Wnt/β-catenin 通路治疗肝脏病变的研究。