Parkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12–21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4–8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21–30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.

帕金森病 (PD) 与基底神经节内的病理性神经活动有关。在此，我们分析了接受丘脑底核 (STN； n = 125) 或苍白球内部 (GPi； n = 44) 清醒深部脑刺激手术的 PD 患者的静息态单神经元和局部场电位 (LFP) 活动。 ），并将基于速率和振荡的特征与 UPDRSIII 停药子评分相关联。基于速率的单神经元特征与 PD 症状无关。 STN 单神经元和 LFP 低 β (12-21 Hz) 功率和突发动态显示与运动迟缓和强直严重程度适度相关，而 STN 尖峰训练 theta (4-8 Hz) 功率与震颤严重程度适度相关。 GPi 低和高 β (21-30 Hz) 功率和突发动态与运动迟缓和轴症状严重程度呈中等相关。这些发现表明，单神经元和 LFP 振荡升高可能与症状有关，尽管适度的相关性意味着 PD 的病理生理学可能超出静息态 β 振荡。