Antimicrobial resistance (AMR) is a global health threat. This randomized controlled trial evaluates the impact of experiential virtual reality (VR) versus information provision via VR or leaflet on prudent antibiotic use. A total of 249 (239 analyzed) participants were randomized into three conditions: VR Information + Experience, VR Information, or Leaflet Information. All participants received AMR information, while those in the VR Information + Experience condition additionally engaged in a game, making treatment decisions for their virtual avatar’s infection. Participants in the VR Information + Experience condition showed a significant increase in prudent use intentions from baseline (d = 1.48). This increase was significantly larger compared to the VR Information (d = 0.50) and Leaflet Information (d = 0.79) conditions. The increase in intentions from baseline remained significant at follow-up in the VR Information + Experience condition (d = 1.25). Experiential VR communication shows promise for promoting prudent antibiotics use.

抗菌素耐药性（AMR）是一个全球性的健康威胁。这项随机对照试验评估了体验式虚拟现实 (VR) 与通过 VR 或传单提供的信息对谨慎使用抗生素的影响。总共 249 名（分析了 239 名）参与者被随机分为三种情况：VR 信息 + 体验、VR 信息或传单信息。所有参与者都收到了 AMR 信息，而处于 VR 信息 + 体验状态的参与者还参与了游戏，为虚拟化身的感染做出治疗决策。 VR 信息 + 体验条件下的参与者表现出谨慎使用意图较基线显着增加 ( d = 1.48)。与 VR 信息 ( d = 0.50) 和 Leaflet 信息 ( d = 0.79) 条件相比，这种增加明显更大。在 VR 信息 + 体验条件下（ d = 1.25），随访时意图相对于基线的增加仍然显着。体验式 VR 交流有望促进谨慎使用抗生素。