Adaptive deep brain stimulation (DBS) improves motor symptoms and quality of life in people with Parkinson disease compared with continuous DBS, the results of a pilot trial suggest. The study included four people with Parkinson disease, each of whom received continuous and adaptive DBS at different times to enable comparison of the effects. Adaptive stimulation was personalized according to motor cortical signals that were identified as biomarkers of fluctuations in motor function. When compared with the effects of continuous stimulation in each individual, adaptive stimulation reduced the time with motor symptoms and improved the participants’ quality of life with respect to normal daily activities.

一项试点试验的结果表明，与连续 DBS 相比，适应性脑深部刺激 （DBS） 可改善帕金森病患者的运动症状和生活质量。该研究包括 4 名帕金森病患者，他们每个人都在不同时间接受了连续和适应性 DBS，以比较效果。适应性刺激根据被确定为运动功能波动生物标志物的运动皮层信号进行个性化。与对每个人的持续刺激效果相比，适应性刺激减少了出现运动症状的时间，并改善了参与者在正常日常活动方面的生活质量。