A pro-inflammatory serum profile has been associated with frontotemporal lobar degeneration (FLTD) in new research, increasing the likelihood that blood-based biomarkers can be used for assessment of neuroinflammation in people with dementia. The researchers analysed cytokines in the serum of 214 people with syndromes associated with FTLD and 29 healthy individuals. Their analysis identified a profile of pro-inflammatory cytokines that was associated with FLTD. Stronger expression of this serum profile was associated with greater central neuroinflammation, as indicated by evidence of microglial activation on PET imaging, and with shorter survival.

中文翻译：

---

血液检查提示额颞叶变性中的中枢性炎症

在新研究中，促炎血清谱与额颞叶变性 （FLTD） 相关，增加了基于血液的生物标志物可用于评估痴呆患者神经炎症的可能性。研究人员分析了 214 名患有 FTLD 相关综合征的人和 29 名健康个体的血清中的细胞因子。他们的分析确定了与 FLTD 相关的促炎细胞因子的概况。这种血清谱的表达更强与更大的中枢神经炎症相关，正如 PET 成像上小胶质细胞激活的证据所示，并且生存期较短。