How are Rab GTPases regulated during lysosome-related organelle (LRO) biogenesis? Li et al. (https://doi.org/10.1083/jcb.202402016) identify LYSMD proteins as crucial activators of Rab32-family GTPases in LRO development, shedding light on the previously ambiguous mechanisms governing Rab functionality in this process.

中文翻译：

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溶酶体相关细胞器生物发生的新参与者。


Rab GTPases 在溶酶体相关细胞器 (LRO) 生物发生过程中如何受到调节？李等人。 (https://doi.org/10.1083/jcb.202402016) 确定 LYSMD 蛋白是 LRO 开发中 Rab32 家族 GTPases 的关键激活剂，揭示了在此过程中控制 Rab 功能的先前模糊机制。