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Supramolecular gels: a versatile crystallization toolbox
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-09-11 , DOI: 10.1039/d4cs00271g Rafael Contreras-Montoya 1 , Luis Álvarez de Cienfuegos 2 , José A Gavira 3 , Jonathan W Steed 4
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-09-11 , DOI: 10.1039/d4cs00271g Rafael Contreras-Montoya 1 , Luis Álvarez de Cienfuegos 2 , José A Gavira 3 , Jonathan W Steed 4
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Supramolecular gels are unique materials formed through the self-assembly of molecular building blocks, typically low molecular weight gelators (LMWGs), driven by non-covalent interactions. The process of crystallization within supramolecular gels has broadened the scope of the traditional gel-phase crystallization technique offering the possibility of obtaining crystals of higher quality and size. The broad structural diversity of LMWGs allows crystallization in multiple organic and aqueous solvents, favouring screening and optimization processes and the possibility to search for novel polymorphic forms. These supramolecular gels have been used for the crystallization of inorganic, small organic compounds of pharmaceutical interest, and proteins. Results have shown that these gels are not only able to produce crystals of high quality but also to influence polymorphism and physicochemical properties of the crystals, giving rise to crystals with potential new bio- and technological applications. Thus, understanding the principles of crystallization in supramolecular gels is essential for tailoring their properties and applications, ranging from drug delivery systems to composite crystals with tunable stability properties. In this review, we summarize the use of LMWG-based supramolecular gels as media to grow single crystals of a broad range of compounds.
中文翻译：
超分子凝胶：多功能结晶工具箱
超分子凝胶是通过分子构建单元（通常是低分子量凝胶剂 （LMWG））的自组装形成的独特材料，由非共价相互作用驱动。超分子凝胶内的结晶过程拓宽了传统凝胶相结晶技术的范围，为获得更高质量和尺寸的晶体提供了可能性。LMWG 的广泛结构多样性允许在多种有机和水性溶剂中结晶，有利于筛选和优化过程以及寻找新型多晶型的可能性。这些超分子凝胶已用于制药目的无机小有机化合物和蛋白质的结晶。结果表明，这些凝胶不仅能够产生高质量的晶体，而且还能够影响晶体的多晶型和物理化学性质，从而产生具有潜在新生物和技术应用的晶体。因此，了解超分子凝胶中的结晶原理对于定制其特性和应用至关重要，从药物递送系统到具有可调稳定性的复合晶体。在这篇综述中，我们总结了使用基于 LMWG 的超分子凝胶作为培养基来培养多种化合物的单晶。
更新日期：2024-09-11
中文翻译：
超分子凝胶：多功能结晶工具箱
超分子凝胶是通过分子构建单元（通常是低分子量凝胶剂 （LMWG））的自组装形成的独特材料，由非共价相互作用驱动。超分子凝胶内的结晶过程拓宽了传统凝胶相结晶技术的范围，为获得更高质量和尺寸的晶体提供了可能性。LMWG 的广泛结构多样性允许在多种有机和水性溶剂中结晶，有利于筛选和优化过程以及寻找新型多晶型的可能性。这些超分子凝胶已用于制药目的无机小有机化合物和蛋白质的结晶。结果表明，这些凝胶不仅能够产生高质量的晶体，而且还能够影响晶体的多晶型和物理化学性质，从而产生具有潜在新生物和技术应用的晶体。因此，了解超分子凝胶中的结晶原理对于定制其特性和应用至关重要，从药物递送系统到具有可调稳定性的复合晶体。在这篇综述中，我们总结了使用基于 LMWG 的超分子凝胶作为培养基来培养多种化合物的单晶。
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