Enhanced Stable and Efficient of Dual-Ligand Zirconium-Based Metal-Organic Frameworks for Synergistic Photodynamic Inactivation,Small

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Enhanced Stable and Efficient of Dual-Ligand Zirconium-Based Metal-Organic Frameworks for Synergistic Photodynamic Inactivation
Small ( IF 13.0 ) Pub Date : 2024-09-11 , DOI: 10.1002/smll.202406171
Jin Xu ₁ , Zhaoyang Ding _{1,

2,

3} , Mingying Wang ₁ , Gan Wu ₁ , Jing Xie _{1,

3}

Affiliation

Porphyrins, known for generating toxic singlet oxygen (¹O₂) to combat bacteria, face challenges such as hydrophilicity and limited lifespan and ¹O₂ yield. Conversely, triterpenoid compounds like ammonium glycyrrhizinate (AG) offer antioxidative and antibacterial properties but lack efficacy and stability. Combining them in Metal-Organic Frameworks (MOFs) yields dual-ligand zirconium (Zr)-basedMOFs (M-TG), capitalizing on porphyrins' membrane-disrupting ability and AG's inhibition of bacterial membrane synthesis for a synergistic antibacterial effect. M-TG resolves activity loss, enhances reactive oxygen species (ROS) yield, and extends stability, achieving a remarkable 99.999% sterilization rate. This innovative approach maximizes ligand properties through synergistic effects, promising significant advancements in antibacterial material design.

中文翻译：

增强的双配体锆基金属有机框架的稳定性和效率，用于协同光动力灭活

卟啉以产生有毒单线态氧（¹O₂）来对抗细菌而闻名，但面临亲水性、使用寿命有限和 ¹O₂ 产率等挑战。相反，甘草酸铵（AG）等三萜类化合物具有抗氧化和抗菌特性，但缺乏功效和稳定性。将它们结合在金属有机框架（MOF）中可产生基于双配体锆（Zr）的 MOF （M-TG），利用卟啉的膜破坏能力和 AG 对细菌膜合成的抑制，从而产生协同抗菌作用。M-TG 解决了活性损失，提高了活性氧（ROS）产量，并延长了稳定性，实现了惊人的 99.999% 灭菌率。这种创新方法通过协同效应最大限度地提高配体性能，有望在抗菌材料设计方面取得重大进展。

更新日期：2024-09-11

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