Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner,Journal of Agricultural and Food Chemistry

当前位置： X-MOL 学术 › J. Agric. Food Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-11 , DOI: 10.1021/acs.jafc.4c03502
Yanli Zhang _{1,

2} , Jianfeng Huang ₁ , Shengpeng Li ₂ , Junlin Jiang ₁ , Jiaojiao Sun ₂ , Dan Chen ₂ , Qingfeng Pang _{1,

2} , Yaxian Wu _{1,

2}

Affiliation

Radiation-induced lung injury (RILI) is a prevalent complication of thoracic tumor radiotherapy and accidental radiation exposure. Pyrroloquinoline quinone (PQQ), a novel vitamin B, plays a crucial role in delaying aging, antioxidation, anti-inflammation, and antiapoptosis. This study aims to investigate the protective effect and mechanisms of PQQ against RILI. C57BL/6 mice were exposed to a 20 Gy dose of X-ray radiation on the entire thorax with or without daily oral administration of PQQ for 2 weeks. PQQ effectively mitigated radiation-induced lung tissue damage, inflammation, oxidative stress, and epithelial cell apoptosis. Additionally, PQQ significantly inhibited oxidative stress and mitochondrial damage in MLE-12 cells. Mechanistically, PQQ upregulated the mRNA and protein levels of MOTS-c in irradiated lung tissue and MLE-12 cells. Knockdown of MOTS-c by siRNA substantially attenuated the protective effects of PQQ on oxidative stress, inflammation, and apoptosis. In conclusion, PQQ alleviates RILI by preserving mitochondrial function through a MOTS-c-dependent mechanism, suggesting that PQQ may serve as a promising nutraceutical intervention against RILI.

中文翻译：

吡咯喹啉醌以 MOTS-c 依赖性方式减轻辐射引起的肺损伤中的线粒体损伤

放射性肺损伤（RILI）是胸部肿瘤放疗和意外辐射暴露的常见并发症。吡咯喹啉醌（PQQ）是一种新型维生素B，在延缓衰老、抗氧化、抗炎、抗细胞凋亡等方面发挥着至关重要的作用。本研究旨在探讨PQQ对RILI的保护作用及其机制。 C57BL/6 小鼠整个胸部接受 20 Gy 剂量的 X 射线辐射，每天口服或不口服 PQQ，持续 2 周。 PQQ 有效减轻辐射引起的肺组织损伤、炎症、氧化应激和上皮细胞凋亡。此外，PQQ 显着抑制 MLE-12 细胞中的氧化应激和线粒体损伤。从机制上讲，PQQ 上调受辐射肺组织和 MLE-12 细胞中 MOTS-c 的 mRNA 和蛋白质水平。通过 siRNA 敲低 MOTS-c 显着减弱了 PQQ 对氧化应激、炎症和细胞凋亡的保护作用。总之，PQQ 通过 MOTS-c 依赖性机制保留线粒体功能来减轻 RILI，这表明 PQQ 可能作为一种有前景的针对 RILI 的营养干预措施。

更新日期：2024-09-11

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南