Single-Molecule Surface-Enhanced Raman Spectroscopy: Challenges, Opportunities, and Future Directions,ACS Nano

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Single-Molecule Surface-Enhanced Raman Spectroscopy: Challenges, Opportunities, and Future Directions
ACS Nano ( IF 15.8 ) Pub Date : 2024-09-11 , DOI: 10.1021/acsnano.4c09483
Makayla Maxine Schmidt ₁ , Alexandre G Brolo ₂ , Nathan C Lindquist ₁

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Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) is a powerful experimental technique for label-free sensing, imaging, and chemical analysis. Although Raman spectroscopy itself is an extremely “feeble” phenomenon, the intense interaction of optical fields with metallic nanostructures in the form of plasmonic hotspots can generate Raman signals from single molecules. While what constitutes a true single-molecule signal has taken some years for the scientific community to establish, many SERS experiments, even those not specifically attempting single-molecule sensitivity, have observed fluctuation in both the SERS intensity and spectral features. In this Perspective, we discuss the impact that fluctuating SERS signals have had on the continuing advancement of SM-SERS, along with challenges and current and potential future applications.

中文翻译：

单分子表面增强拉曼光谱：挑战、机遇和未来方向

单分子表面增强拉曼光谱 (SM-SERS) 是一种用于无标记传感、成像和化学分析的强大实验技术。尽管拉曼光谱本身是一种极其“微弱”的现象，但光场与等离子体热点形式的金属纳米结构的强烈相互作用可以从单分子产生拉曼信号。虽然科学界花了数年时间才确定真正的单分子信号的构成，但许多 SERS 实验，即使是那些没有专门尝试单分子灵敏度的实验，也观察到了 SERS 强度和光谱特征的波动。在本视角中，我们讨论了波动的 SERS 信号对 SM-SERS 持续发展的影响，以及挑战以及当前和潜在的未来应用。

更新日期：2024-09-11

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