Chemoselective Approach to Versatile Acyl Fluorides by Photoinduced Activation of p-Methoxybenzyl Esters,Organic Letters

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Chemoselective Approach to Versatile Acyl Fluorides by Photoinduced Activation of p-Methoxybenzyl Esters
Organic Letters ( IF 4.9 ) Pub Date : 2024-09-11 , DOI: 10.1021/acs.orglett.4c03008
Hee-Chan Jeong ₁ , Hyo-Jun Lee ₁ , Keiji Maruoka _{2,

3}

Affiliation

A new strategy for the metal-free photoinduced activation of p-methoxybenzyl esters is developed using Selectfluor and benzil for the generation of acyl fluoride intermediates that enable various transformations. The highlight of this activation method is its high chemoselectivity in the presence of other functionalities, such as esters, amides, and ketones. A synthetic application for the preparation of peptide mimetics that possess two different amide units is also described.

中文翻译：

通过对甲氧基苄酯的光诱导活化对多功能酰基氟化物进行化学选择性方法

使用 Selectflor 和苯偶酰开发了一种无金属光诱导活化对甲氧基苯甲基酯的新策略，以生成能够实现各种转化的酰基氟化物中间体。这种活化方法的亮点是在存在其他官能团（例如酯、酰胺和酮）的情况下具有高化学选择性。还描述了制备具有两种不同酰胺单元的肽模拟物的合成应用。

更新日期：2024-09-11

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