We quantified the proportion of diagnoses of pulmonary fibrosis (PF) among 25 136 people with lung cancer and 250 583 matched controls and compared the natural history of lung cancer in people with and without PF. Diagnoses of PF were more common in people with lung cancer than those without (1.5% vs 0.8%, OR 1.97; 95% CI 1.77 to 2.21). Within people with PF, squamous cell carcinoma was more (22.9% vs 19.1%), and adenocarcinoma was less common (18.0% vs 21.3%). People with PF were less likely to have stage 4 disease at diagnosis (OR 0.43, 95% CI 0.28 to 0.65) but their survival was worse. Data may be obtained from a third party and are not publicly available. Data are available through CPRD and NCRAS.

中文翻译：

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肺纤维化和肺癌：与国家癌症登记数据集相关的临床实践研究数据链分析


我们量化了 25 136 名肺癌患者和 250 583 名匹配对照者中诊断出肺纤维化 (PF) 的比例，并比较了患有和不患有 PF 的人的肺癌自然史。肺癌患者中 PF 的诊断比非肺癌患者更常见（1.5% vs 0.8%，OR 1.97；95% CI 1.77 至 2.21）。在 PF 患者中，鳞状细胞癌较多见（22.9% vs 19.1%），腺癌较少见（18.0% vs 21.3%）。 PF 患者在诊断时患 4 期疾病的可能性较小（OR 0.43，95% CI 0.28 至 0.65），但他们的生存率较差。数据可能从第三方获得，并且不公开。数据可通过 CPRD 和 NCRAS 获取。