Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells can be isolated from muscle but cannot be propagated successfully in culture in numbers needed for therapeutic use. We developed a method to generate cells with satellite cell characteristics from skeletal muscle organoid cultures.

中文翻译：

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体外去分化成肌细胞回到卫星细胞状态


卫星细胞是骨骼肌的干细胞，负责肌肉的发育和再生。虽然卫星细胞丰度较低，但可以从肌肉中分离出来，但无法在培养物中成功繁殖达到治疗用途所需的数量。我们开发了一种从骨骼肌类器官培养物中产生具有卫星细胞特征的细胞的方法。