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使用3D结构化肽针对VEGF上的贝伐单抗结合位点进行定向疫苗接种可产生有效的抗肿瘤活性[化学]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2016-11-01 11:38:51 , DOI: 10.1073/pnas.1610258113
Madelon Q. Wentink 1 , Tilman M. Hackeng 2 , Sebastien P. Tabruyn 1 , Wouter C. Puijk 3 , Klaus Schwamborn 3 , Daniele Altschuh 4 , Rob H. Meloen 3 , Teun Schuurman 5 , Arjan W. Griffioen 1 , Peter Timmerman 3, 6
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2016-11-01 11:38:51 , DOI: 10.1073/pnas.1610258113
Madelon Q. Wentink 1 , Tilman M. Hackeng 2 , Sebastien P. Tabruyn 1 , Wouter C. Puijk 3 , Klaus Schwamborn 3 , Daniele Altschuh 4 , Rob H. Meloen 3 , Teun Schuurman 5 , Arjan W. Griffioen 1 , Peter Timmerman 3, 6
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VEGF中和性单克隆抗体贝伐单抗对VEGF信号轴的治疗靶向已明确证明对癌症患者具有临床益处。为了使用多克隆方法改善这一策略，我们使用模仿贝伐单抗结合位点的3D结构肽开发了靶向VEGF的疫苗。多肽优化的深入研究...
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更新日期：2016-11-03
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