Chirality in Insecticide Design and Efficacy,Journal of Agricultural and Food Chemistry

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Chirality in Insecticide Design and Efficacy
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-10 , DOI: 10.1021/acs.jafc.4c05363
Karla Irazú Ventura-Hernández _{1,

2} , Enrique Delgado-Alvarado ₃ , Tushar Janardan Pawar ₁ , José Luis Olivares-Romero ₁

Affiliation

Chirality plays a crucial role in the design and efficacy of insecticides, significantly influencing their biological activity, selectivity, and environmental impact. Recent advancements in chiral insecticides have focused on enhancing their effectiveness, reducing toxicity to nontarget organisms, and improving environmental sustainability. This review provides a comprehensive overview of the current state of knowledge on chiral insecticides, including neonicotinoids, isoxazolines, and sulfiliminyls. We discuss the stereochemistry, synthetic development, mode of action, and environmental fate of these compounds. The review highlights the importance of chirality in optimizing insecticidal properties and underscores the need for continued research into novel chiral compounds and advanced synthesis technologies. By understanding the role of chirality, we can develop more effective and environmentally friendly insecticides for sustainable pest management.

中文翻译：

杀虫剂设计和功效中的手性

手性在杀虫剂的设计和功效中起着至关重要的作用，显着影响其生物活性、选择性和环境影响。手性杀虫剂的最新进展集中在提高其有效性、降低对非目标生物的毒性以及改善环境可持续性。本综述全面概述了手性杀虫剂（包括新烟碱类杀虫剂、异恶唑啉类和硫亚胺类杀虫剂）的当前知识状况。我们讨论这些化合物的立体化学、合成开发、作用方式和环境归宿。该综述强调了手性在优化杀虫特性方面的重要性，并强调需要继续研究新型手性化合物和先进合成技术。通过了解手性的作用，我们可以开发更有效、更环保的杀虫剂，以实现害虫的可持续治理。

更新日期：2024-09-10

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