Combining High-Resolution Mass Spectrometry and Chemiluminescence Analysis to Characterize the Composition and Fate of Total N-Nitrosamines in Wastewater Treatment Plants,Environmental Science & Technology

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Combining High-Resolution Mass Spectrometry and Chemiluminescence Analysis to Characterize the Composition and Fate of Total N-Nitrosamines in Wastewater Treatment Plants
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2024-09-10 , DOI: 10.1021/acs.est.4c06555
Changcheng Pu ₁ , Benjamin R Cavarra ₁ , Teng Zeng ₁

Affiliation

Monitoring the prevalence and persistence of N-nitrosamines and their precursors in wastewater treatment plants (WWTPs) and effluent-receiving aquatic compartments is a priority for utilities practicing wastewater recycling or exploiting wastewater-impacted source waters. In this work, we developed an analytical framework that combines liquid chromatography-high-resolution mass spectrometry (LC-HRMS) with acidic triiodide-chemiluminescence analysis to characterize the composition and fate of total N-nitrosamines (TONO) and their precursors along the treatment trains of eight WWTPs in New York. Through the parallel application of LC-HRMS and chemiluminescence methods, the TONO scores for 41 N-nitrosamines containing structurally diverse substituents on their amine nitrogen were derived based on their solid-phase extraction recoveries and conversion efficiencies to nitric oxide. Correcting the compositional analysis of TONO using the TONO scores of target N-nitrosamines refined the assessment of the reduction or accumulation of TONO and their precursors across treatment steps in WWTPs. Nontargeted analysis prioritized seven additional N-nitrosamines for confirmation by reference standards, including three previously uncharacterized species: N-nitroso-tert-butylphenylamine, N-nitroso-2-pyrrolidinmethanol, and N-nitrosodesloratadine, although they only served as minor components of TONO. Overall, our study establishes an adaptable methodological framework for advancing the quantitative and qualitative analysis of specific and unknown components of TONO across water treatment and reuse scenarios.

中文翻译：

结合高分辨率质谱和化学发光分析来表征废水处理厂中总 N-亚硝胺的组成和去向

监测废水处理厂 (WWTP) 和污水接收水体隔室中N-亚硝胺及其前体的普遍性和持久性是实行废水回收或利用受废水影响的水源水的公用事业公司的首要任务。在这项工作中，我们开发了一个分析框架，将液相色谱-高分辨率质谱 (LC-HRMS) 与酸性三碘化物化学发光分析相结合，以表征总N-亚硝胺 (TONO) 及其前体在处理过程中的组成和去向。纽约八个污水处理厂的列车。通过并行应用 LC-HRMS 和化学发光方法，根据固相萃取回收率和一氧化氮的转化效率，得出胺氮上含有结构不同取代基的 41 N -亚硝胺的 TONO 评分。使用目标N -亚硝胺的 TONO 分数校正 TONO 的成分分析，改进了对污水处理厂处理步骤中 TONO 及其前体的减少或积累的评估。非靶向分析优先考虑了另外 7 种N-亚硝胺，通过参考标准进行确认，包括三种以前未表征的物质： N-亚硝基叔丁基苯胺、 N-亚硝基-2-吡咯烷甲醇和N-亚硝基地氯雷他定，尽管它们仅作为 TONO 的次要成分。总体而言，我们的研究建立了一个适应性强的方法框架，用于推进水处理和再利用场景中 TONO 特定和未知成分的定量和定性分析。

更新日期：2024-09-10

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