Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).

中文翻译：

---

邻居的反馈有助于巨噬细胞学习肠道耐受性

肠道巨噬细胞在调节肠道免疫耐受中发挥着关键作用。在本期《免疫》中，Mertens 等人。揭示了肠道中巨噬细胞耐受性记忆建立的机制，涉及巨噬细胞中的双稳态代谢开关以及巨噬细胞和肠上皮细胞（IEC）之间的细胞间正反馈。