Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

中文翻译：

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抗衰老疫苗：卡介苗逆转髓鞘再生失败

衰老会导致一些变化，从而加速或加重我们一生中发生的多种疾病。在中枢神经系统中，衰老会影响维持和修复髓鞘的能力，髓鞘保护轴突并促进神经元信号传导。蒂瓦里等人。报道了脱髓鞘后小胶质细胞中与衰老相关的转录反应，这种反应可以通过卡介苗接种后的表观遗传重塑来逆转。