Tissue-resident memory CD8⁺ T cells serve as a first-line defense against many pathogens. In this issue of Immunity, Buquicchio et al. unveil the epigenomic landscapes of virus-specific CD8⁺ T cell subsets, highlighting common and organ-specific regulators driving their differentiation.

中文翻译：

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组织特异性免疫记忆的表观基因组矩阵

组织驻留记忆 CD8 ⁺ T 细胞是对抗许多病原体的一线防御。在本期《免疫》中，Buquicchio 等人。揭示了病毒特异性 CD8 ⁺ T 细胞亚群的表观基因组景观，强调了驱动其分化的常见和器官特异性调节因子。