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Neohesperidin Attenuates DSS-Induced Ulcerative Colitis by Inhibiting Inflammation, Reducing Intestinal Barrier Damage, and Modulating Intestinal Flora Composition
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-09 , DOI: 10.1021/acs.jafc.4c04433 Tianyuan Ju 1 , Zheyu Song 2 , Di Qin 1 , Ji Cheng 1 , Tong Li 1 , Guiqiu Hu 1 , Shoupeng Fu 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-09-09 , DOI: 10.1021/acs.jafc.4c04433 Tianyuan Ju 1 , Zheyu Song 2 , Di Qin 1 , Ji Cheng 1 , Tong Li 1 , Guiqiu Hu 1 , Shoupeng Fu 1
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Flavonoid natural products are emerging as a promising approach for treating Ulcerative Colitis (UC) due to their natural origin and minimal toxicity. This study investigates the effects of Neohesperidin (NEO), a natural flavonoid, on Dextran Sodium Sulfate (DSS)-induced UC in mice, focusing on the underlying molecular mechanisms. Early intervention with NEO (25 and 50 mg/kg) mitigated colon shortening, restored damaged barrier proteins, and significantly reduced the inflammatory cytokine levels. Moreover, NEO inhibited the MAPK/NF-κB signaling pathway and enhanced the levels of intestinal barrier proteins (Claudin-3 and ZO-1). Additionally, NEO increased beneficial intestinal probiotics (S24–7 and Lactobacillaceae) while reducing harmful bacteria (Erysipelotrichi, Enterobacteriaceae). Fecal microbial transplantation (FMT) results demonstrated that NEO (50 mg/kg) markedly improved UC symptoms. In conclusion, early NEO intervention may alleviate DSS-induced UC by inhibiting inflammatory responses, preserving intestinal barrier integrity and modulating gut microbiota.
中文翻译：
新橙皮苷通过抑制炎症、减少肠道屏障损伤和调节肠道菌群组成来减轻 DSS 诱发的溃疡性结肠炎
类黄酮天然产品因其天然来源和最小毒性而成为治疗溃疡性结肠炎 (UC) 的一种有前景的方法。本研究探讨了新橙皮苷 (NEO)（一种天然类黄酮）对右旋糖酐硫酸钠 (DSS) 诱导的小鼠 UC 的影响，重点关注其潜在的分子机制。 NEO（25 和 50 mg/kg）的早期干预可减轻结肠缩短，恢复受损的屏障蛋白，并显着降低炎症细胞因子水平。此外，NEO 抑制 MAPK/NF-κB 信号通路并提高肠道屏障蛋白（Claudin-3 和 ZO-1）的水平。此外，NEO 增加了有益的肠道益生菌（ S24-7和乳杆菌科），同时减少了有害细菌（丹毒菌、肠杆菌科）。粪便微生物移植（FMT）结果表明NEO（50 mg/kg）显着改善UC症状。总之，早期 NEO 干预可能通过抑制炎症反应、保护肠道屏障完整性和调节肠道微生物群来缓解 DSS 诱导的 UC。
更新日期：2024-09-09
中文翻译：
新橙皮苷通过抑制炎症、减少肠道屏障损伤和调节肠道菌群组成来减轻 DSS 诱发的溃疡性结肠炎
类黄酮天然产品因其天然来源和最小毒性而成为治疗溃疡性结肠炎 (UC) 的一种有前景的方法。本研究探讨了新橙皮苷 (NEO)（一种天然类黄酮）对右旋糖酐硫酸钠 (DSS) 诱导的小鼠 UC 的影响，重点关注其潜在的分子机制。 NEO（25 和 50 mg/kg）的早期干预可减轻结肠缩短，恢复受损的屏障蛋白，并显着降低炎症细胞因子水平。此外，NEO 抑制 MAPK/NF-κB 信号通路并提高肠道屏障蛋白（Claudin-3 和 ZO-1）的水平。此外，NEO 增加了有益的肠道益生菌（ S24-7和乳杆菌科），同时减少了有害细菌（丹毒菌、肠杆菌科）。粪便微生物移植（FMT）结果表明NEO（50 mg/kg）显着改善UC症状。总之，早期 NEO 干预可能通过抑制炎症反应、保护肠道屏障完整性和调节肠道微生物群来缓解 DSS 诱导的 UC。
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