Background/aims We evaluated longitudinal autoantibody changes after intravenous methylprednisolone (IVMP), compared them with those in untreated patients and identified prognostic factors for treatment response. Methods In this single-centre, retrospective, observational study, a total of 163 individuals diagnosed with moderate-to-severe thyroid eye disease were enrolled and followed for 12 months. Depending on whether IVMP was administered, we divided the patients into treatment and control groups. Based on the effect of IVMP on TSH receptor (TSH Rc) antibody level, we divided the patients into Ab declined and Ab not declined groups. We evaluated the time, group and interaction associations with the longitudinal autoantibody titres over 12 months using generalised estimating equations. Using multivariable logistic regression, we investigated the prognostic factors for a poor response to IVMP. Results In the IVMP group, the TSH Rc antibody (Ab) titre decreased rapidly for 6 months and then decreased slowly until 12 months, becoming similar to the control group at 12 months. This suggests a difference in the decreasing pattern over time between the IVMP and control groups (group and time interaction p=0.029). Total cholesterol (OR 1.0217 (95% CI 1.0068 to 1.0370), p=0.0043) was a significant prognostic factor for the steroid response. The threshold total cholesterol value to distinguish between Ab declined and Ab not declined was 186 mg/dL. Conclusion IVMP significantly decreased the TSH Rc Ab level for the 3 months after treatment, compared with the no-treatment group, but the groups did not differ significantly after 12 months. Patients with high total cholesterol levels generally showed a poor response to IVMP. Data are available on reasonable request. The datasets produced during and/or examined in the course of our present study can be obtained if requested to the author.

中文翻译：

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静脉注射甲基强的松龙对甲状腺眼病患者血清抗体水平的影响


背景/目的 我们评估了静脉注射甲泼尼龙（IVMP）后纵向自身抗体的变化，将其与未经治疗的患者进行比较，并确定治疗反应的预后因素。方法 在这项单中心、回顾性、观察性研究中，共有 163 名被诊断患有中重度甲状腺眼病的个体入组并随访 12 个月。根据是否进行 IVMP，我们将患者分为治疗组和对照组。根据IVMP对TSH受体（TSH Rc）抗体水平的影响，我们将患者分为Ab下降组和Ab未下降组。我们使用广义估计方程评估了 12 个月内时间、组别和相互作用与纵向自身抗体滴度的关联。使用多变量逻辑回归，我们研究了 IVMP 反应不佳的预后因素。结果 IVMP组TSH Rc抗体（Ab）滴度在6个月内快速下降，然后缓慢下降，直到12个月，12个月时与对照组相似。这表明 IVMP 组和对照组之间随着时间的推移下降模式存在差异（组和时间交互作用 p=0.029）。总胆固醇（OR 1.0217（95% CI 1.0068 至 1.0370），p=0.0043）是类固醇反应的重要预后因素。区分抗体下降和抗体未下降的阈值总胆固醇值为 186 mg/dL。结论 与未治疗组相比，IVMP治疗后3个月TSH Rc Ab水平显着降低，但12个月后各组间无显着差异。总胆固醇水平高的患者通常对 IVMP 反应较差。可根据合理要求提供数据。 如果作者提出要求，可以获取我们当前研究过程中生成和/或检查的数据集。