Purpose To create a computational fluid dynamics (CFD) model of ocular anterior segment for primary angle closure diseases (PACD) and assess the aqueous humour (AH) dynamics in different angle closure ranges (ACRs). Methods The ocular anterior segment geometry was obtained from an optical coherence tomography image by SOLIDWORKS. Three different angle opening distance at 750 µm from the scleral spur (AOD750) values were established to mimic three widths of anterior chamber angle. The AH dynamics were modelled using the Navier-Stokes equation. The 3D CFD model of the ocular anterior segment was created in COMSOL Multiphysics. The major outcome was the maximum flow velocity (MFV) and pressure in the ocular anterior segment. An in vitro simulation model was used to validate the computational results of the pressure and ACRs. Results The MFV and pressure both showed a non-linear association with ACR in the CFD models of PACD. The MFV and pressure started to elevate when ACR was larger than 180°, and increased dramatically when the ACR was larger than 270°. The in vitro experiment of the pressure changes was consistent with the CFD model. No significant differences of the MFV and pressure among the three AOD750 models. Conclusions The association among the ACR, MFV and pressure is an ascending curve in PACD, and ACR of 180° and 270° are two critical turning points. Our results are consistent with clinical phenomenon and may be used to provide better guidances for the clinical management of PACD in different stages. Data are available upon reasonable request. Data can be acquired from the corresponding author upon reasonable request.

中文翻译：

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原发性闭角疾病中的房水动力学：一项计算研究


目的 创建原发性闭角疾病 (PACD) 的眼前节计算流体动力学 (CFD) 模型，并评估不同闭角范围 (ACR) 下的房水 (AH) 动力学。方法通过 SOLIDWORKS 从光学相干断层扫描图像获得眼前节几何形状。建立距离巩膜刺 (AOD750) 值 750 µm 处的三个不同角度张开距离，以模拟三种前房角宽度。 AH 动力学使用纳维-斯托克斯方程进行建模。眼前节的 3D CFD 模型是在 COMSOL Multiphysics 中创建的。主要结果是眼前节的最大流速（MFV）和压力。使用体外模拟模型来验证压力和 ACR 的计算结果。结果 PACD 的 CFD 模型中 MFV 和压力均与 ACR 呈非线性关系。当ACR大于180°时，MFV和压力开始升高，当ACR大于270°时，MFV和压力急剧增加。体外实验的压力变化与CFD模型一致。三个 AOD750 型号之间的 MFV 和压力没有显着差异。结论 PACD 中 ACR、MFV 与压力之间呈上升曲线，其中 180° 和 270° ACR 是两个关键转折点。我们的结果与临床现象一致，可以为PACD不同阶段的临床管理提供更好的指导。数据可根据合理要求提供。根据合理要求，可以从通讯作者处获取数据。