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DNA-templated fluorescent metal nanoclusters and their illuminating applications
Nanoscale ( IF 5.8 ) Pub Date : 2024-09-10 , DOI: 10.1039/d4nr03429e Ashwin Rajeev 1 , Dhiraj Bhatia 1
Nanoscale ( IF 5.8 ) Pub Date : 2024-09-10 , DOI: 10.1039/d4nr03429e Ashwin Rajeev 1 , Dhiraj Bhatia 1
Affiliation
After the discovery of DNA during the mid-20th century, a multitude of novel methodologies have surfaced which exploit DNA for its various properties. One such recently developed application of DNA is as a template in metal nanocluster formation. In the early years of the new millennium, a group of researchers found that DNA can be adopted as a template for the binding of metal nanoparticles that ultimately form nanoclusters. Three metal nanoclusters have been studied so far, including silver, gold, and copper, which have a plethora of biological applications. This review focuses on the synthesis, mechanisms, and novel applications of DNA-templated metal nanoclusters, including the therapies that have employed them for their wide range of fluorescent properties, and the future perspectives related to their development by exploiting machine learning algorithms and molecular dynamics simulation studies.
中文翻译:
DNA 模板荧光金属纳米簇及其照明应用
在 20 世纪中叶发现 DNA 后,出现了许多利用 DNA 的各种特性的新方法。DNA 最近开发的一种应用是作为金属纳米簇形成的模板。在新千年的早期,一组研究人员发现 DNA 可以作为结合金属纳米颗粒的模板,最终形成纳米团簇。到目前为止,已经研究了三种金属纳米团簇,包括银、金和铜,它们具有大量的生物学应用。本文重点介绍了 DNA 模板化金属纳米团簇的合成、机制和新应用,包括利用它们广泛的荧光特性的疗法,以及通过利用机器学习算法和分子动力学模拟研究与它们的发展相关的未来前景。
更新日期:2024-09-10
中文翻译:
DNA 模板荧光金属纳米簇及其照明应用
在 20 世纪中叶发现 DNA 后,出现了许多利用 DNA 的各种特性的新方法。DNA 最近开发的一种应用是作为金属纳米簇形成的模板。在新千年的早期,一组研究人员发现 DNA 可以作为结合金属纳米颗粒的模板,最终形成纳米团簇。到目前为止,已经研究了三种金属纳米团簇,包括银、金和铜,它们具有大量的生物学应用。本文重点介绍了 DNA 模板化金属纳米团簇的合成、机制和新应用,包括利用它们广泛的荧光特性的疗法,以及通过利用机器学习算法和分子动力学模拟研究与它们的发展相关的未来前景。