In a recent Nature paper, Ruggero and colleagues found that fasting and ketogenic diets induce metabolic rewiring through a translational mechanism involving MNK-mediated phosphorylation of eIF4E, which enhances ketogenesis. This process creates a metabolic vulnerability in pancreatic cancer that could be therapeutically exploited.

中文翻译：

---

造成饮食脆弱性


在最近的一篇《自然》论文中，Ruggero 及其同事发现，禁食和生酮饮食通过涉及 MNK 介导的 eIF4E 磷酸化的翻译机制诱导代谢重新布线，从而增强生酮作用。这一过程在胰腺癌中造成了代谢脆弱性，可以在治疗上利用这一脆弱性。