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Advancements in nanosensors for detecting pathogens in healthcare environments
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2024-09-09 , DOI: 10.1039/d4en00381k Antonia Bruno 1 , Farida Tripodi 1 , Alice Armanni 1 , Linda Barbieri 1 , Alessandro Colombo 1 , Sara Fumagalli 1 , Hind Moukham 1 , Giulia Tomaino 1 , Ekaterina Kukushkina 2 , Roberto Lorenzi 2 , Letizia Marchesi 3 , Angelo Monguzzi 2, 4 , Alberto Paleari 2 , Alessandra Ronchi 2 , Valeria Secchi 2 , Laura Sironi 3, 4 , Miriam Colombo 1, 4
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2024-09-09 , DOI: 10.1039/d4en00381k Antonia Bruno 1 , Farida Tripodi 1 , Alice Armanni 1 , Linda Barbieri 1 , Alessandro Colombo 1 , Sara Fumagalli 1 , Hind Moukham 1 , Giulia Tomaino 1 , Ekaterina Kukushkina 2 , Roberto Lorenzi 2 , Letizia Marchesi 3 , Angelo Monguzzi 2, 4 , Alberto Paleari 2 , Alessandra Ronchi 2 , Valeria Secchi 2 , Laura Sironi 3, 4 , Miriam Colombo 1, 4
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Hospitals serve as critical environments for the management of diverse medical conditions, ranging from routine illnesses to life-threatening emergencies. However, alongside providing healthcare services, hospitals represent reservoirs for the transmission of microbial pathogens. Understanding the distribution and dynamics of pathogens within hospital settings is crucial for effective infection control and prevention strategies. Concurrently, the integration of cutting-edge technologies for the early detection and monitoring of target bacteria stands as a pivotal strategy in this battle against nosocomial infections. This critical review aims to provide a systematic insight into the main threatening microbes in hospitals and the detection of pathogens in different environments, ranging from intensive care units to general wards, including hospital entrances, bathrooms, high-touch surfaces, patient bed rails, medical equipment, and floors, which are often contaminated. We discuss recent scientific and technological advances in pathogen detection by exploring innovative methods that leverage nanotechnology to improve biosensing effectiveness and selectivity. This review is divided into sections focusing on various types of hospital environments, classes of mostly represented pathogens and kinds of available nanobiosensors. We include two comprehensive tables summarizing bacterial contamination in hospital wards and the materials and substrates associated with the nanobiosensors that have been developed. Eventually, we highlight the open challenges and perspectives in nanotechnology-based healthcare-environment monitoring and remediation as a promising solution to counteract pathogen emergence and spread.
中文翻译：
用于检测医疗环境中病原体的纳米传感器的进展
医院是管理各种医疗状况的关键环境，从常规疾病到危及生命的紧急情况。然而，除了提供医疗服务外，医院还是微生物病原体传播的储存库。了解医院环境内病原体的分布和动态对于有效的感染控制和预防策略至关重要。同时，整合尖端技术对目标细菌进行早期检测和监测是对抗医院感染的关键策略。本次批判性审查旨在系统地了解医院中的主要威胁微生物以及不同环境中病原体的检测，从重症监护室到普通病房，包括医院入口、浴室、高接触表面、患者床栏、医疗设施等。设备和地板经常受到污染。我们通过探索利用纳米技术提高生物传感有效性和选择性的创新方法来讨论病原体检测的最新科学和技术进展。本综述分为几个部分，重点关注各种类型的医院环境、主要代表的病原体类别和可用的纳米生物传感器的种类。我们提供了两张综合表格，总结了医院病房的细菌污染以及与已开发的纳米生物传感器相关的材料和基材。最后，我们强调基于纳米技术的医疗保健环境监测和修复中的开放挑战和前景，作为对抗病原体出现和传播的有前途的解决方案。
更新日期：2024-09-09
中文翻译：
用于检测医疗环境中病原体的纳米传感器的进展
医院是管理各种医疗状况的关键环境，从常规疾病到危及生命的紧急情况。然而，除了提供医疗服务外，医院还是微生物病原体传播的储存库。了解医院环境内病原体的分布和动态对于有效的感染控制和预防策略至关重要。同时，整合尖端技术对目标细菌进行早期检测和监测是对抗医院感染的关键策略。本次批判性审查旨在系统地了解医院中的主要威胁微生物以及不同环境中病原体的检测，从重症监护室到普通病房，包括医院入口、浴室、高接触表面、患者床栏、医疗设施等。设备和地板经常受到污染。我们通过探索利用纳米技术提高生物传感有效性和选择性的创新方法来讨论病原体检测的最新科学和技术进展。本综述分为几个部分，重点关注各种类型的医院环境、主要代表的病原体类别和可用的纳米生物传感器的种类。我们提供了两张综合表格，总结了医院病房的细菌污染以及与已开发的纳米生物传感器相关的材料和基材。最后，我们强调基于纳米技术的医疗保健环境监测和修复中的开放挑战和前景，作为对抗病原体出现和传播的有前途的解决方案。
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