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Understanding the role of biomolecular coronas in human exposure to nanomaterials
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2024-09-09 , DOI: 10.1039/d4en00488d Mahmoud G Soliman 1, 2 , Alberto Martinez-Serra 1 , Giulia Antonello 3 , Marko Dobricic 1 , Terence Wilkins 4 , Tommaso Serchi 5 , Ivana Fenoglio 3 , Marco P Monopoli 1
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2024-09-09 , DOI: 10.1039/d4en00488d Mahmoud G Soliman 1, 2 , Alberto Martinez-Serra 1 , Giulia Antonello 3 , Marko Dobricic 1 , Terence Wilkins 4 , Tommaso Serchi 5 , Ivana Fenoglio 3 , Marco P Monopoli 1
Affiliation
Nanomaterials (NMs) are increasingly used in medical treatments, electronics, and food additives. However, nanosafety—the possible adverse effects of NMs on human health—is an area of active research. This review provides an overview of the influence of biomolecular coronas on NM transformation following various exposure routes. We discuss potential exposure pathways, including inhalation and ingestion, describing the physiology of exposure routes and emphasising the relevance of coronas in these environments. Additionally, we review other routes to NM exposure, such as synovial fluid, blood (translocation and injection), dermal and ocular exposure, as well as the dose and medium impact on NM interactions. We emphasize the need for an in-depth characterisation of coronas in different biological media, highlighting the need and opportunity to study lung and gastric fluids to understand NM behaviour and potential toxicity. Future research aims to predict better in vivo outcomes and address the complexities of NM interactions with biological systems.
中文翻译:
了解生物分子电晕在人类暴露于纳米材料中的作用
纳米材料 (NM) 越来越多地用于医疗、电子产品和食品添加剂。然而,纳米安全性(NM 对人类健康可能产生的不利影响)是一个积极研究的领域。本文概述了生物分子电晕对各种暴露途径后 NM 转化的影响。我们讨论了潜在的暴露途径,包括吸入和摄入,描述了暴露途径的生理学,并强调了电晕在这些环境中的相关性。此外,我们回顾了 NM 暴露的其他途径,例如滑液、血液(易位和注射)、皮肤和眼部暴露,以及剂量和媒介对 NM 相互作用的影响。我们强调需要深入表征不同生物介质中的电晕,强调研究肺液和胃液以了解 NM 行为和潜在毒性的必要性和机会。未来的研究旨在预测更好的体内结果并解决 NM 与生物系统相互作用的复杂性。
更新日期:2024-09-09
中文翻译:
了解生物分子电晕在人类暴露于纳米材料中的作用
纳米材料 (NM) 越来越多地用于医疗、电子产品和食品添加剂。然而,纳米安全性(NM 对人类健康可能产生的不利影响)是一个积极研究的领域。本文概述了生物分子电晕对各种暴露途径后 NM 转化的影响。我们讨论了潜在的暴露途径,包括吸入和摄入,描述了暴露途径的生理学,并强调了电晕在这些环境中的相关性。此外,我们回顾了 NM 暴露的其他途径,例如滑液、血液(易位和注射)、皮肤和眼部暴露,以及剂量和媒介对 NM 相互作用的影响。我们强调需要深入表征不同生物介质中的电晕,强调研究肺液和胃液以了解 NM 行为和潜在毒性的必要性和机会。未来的研究旨在预测更好的体内结果并解决 NM 与生物系统相互作用的复杂性。