While chronic limb-threatening ischemia is a serious peripheral artery disease, the lack of an appropriate stent significantly limits the potential of interventional treatment. In spite of much progress in coronary stents, little is towards peripheral stents, which are expected to be both long and biodegradable and thus require a breakthrough in core techniques. Herein, we develop a long and biodegradable stent with a length of up to 118 mm based on a metal-polymer composite material. To achieve a well-prepared homogeneous coating on a long stent during ultrasonic spraying, a magnetic levitation is employed. In vivo degradation of the stent is investigated in rabbit abdominal aorta/iliac arteries, and its preclinical safety is evaluated in canine infrapopliteal arteries. First-in-man implantation of the stent is carried out in the below-the-knee artery. The 13 months’ follow-ups demonstrate the feasibility of the long and biodegradable stent in clinical applications.

虽然慢性肢体威胁性缺血是一种严重的外周动脉疾病，但缺乏合适的支架极大地限制了介入治疗的潜力。尽管冠状动脉支架取得了很大进展，但外周支架的进展却很少，外周支架预计既长又可生物降解，因此需要在核心技术上取得突破。在此，我们开发了一种基于金属聚合物复合材料的长且可生物降解的支架，长度可达118毫米。为了在超声波喷涂过程中在长支架上获得准备充分的均匀涂层，采用了磁悬浮。在兔腹主动脉/髂动脉中研究了支架的体内降解，并在犬腘下动脉中评估了其临床前安全性。支架的首次人体植入是在膝下动脉中进行的。 13个月的随访证明了长可生物降解支架在临床应用的可行性。