Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer's disease based on Cu2+ chelation and photothermal therapy,Journal of Controlled Release

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Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer's disease based on Cu2+ chelation and photothermal therapy
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2024-09-13 , DOI: 10.1016/j.jconrel.2024.09.009
Lianxin Li ₁ , Yu Xiong ₁ , Yuewen Zhang ₁ , Yujiao Yan ₁ , Ruixin Zhao ₁ , Fengmei Yang ₁ , Meng Xie ₁

Affiliation

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases characterized by cognitive and memory impairment. Metal ion imbalance and Mitochondrial dysfunction, leading to abnormal aggregation of β-amyloid protein (Aβ), are key factors in the pathogenesis of AD. Therefore, we designed a composite nanometer system of red blood cell (RBC) membranes-encapsulated Prussian blue nanoparticles (PB/RBC). Prussian blue nanoparticles (PBNPs) can chelate Cu2+ and reduce reactive oxygen species (ROS). The RBC membranes are a kind of natural long-lasting circulating carrier. At the same time, through NIR irradiation, the excellent photothermal ability of PBNPs can also temporarily open the blood-brain barrier (BBB), enhance the transmission efficiency of PB/RBC across the BBB, and depolymerize the formed Aβ deposits, thereby achieving the optimal therapeutic effect. In vitro and in vivo studies demonstrated that PB/RBC could inhibit Cu2+-induced Aβ monomers aggregation, eliminate the deposition of Aβ plaques, improve the quality of mitochondria, restore the phagocytic function of microglia, alleviate neuroinflammation in APP/PS1 mice, and repair memory damage. In conclusion, our biofilm-camouflaged nano-delivery system provides significant neuroprotection by inhibiting Cu2+-induced Aβ monomers aggregation, photothermally depolymerizing Aβ fibrils and reducing the level of ROS, thus effectively ameliorating and treating AD.

中文翻译：

基于 Cu2+ 螯合和光热疗法的生物膜伪装普鲁士蓝协同线粒体质量增强治疗阿尔茨海默病

阿尔茨海默病（AD）是最常见的神经退行性疾病之一，其特征是认知和记忆障碍。金属离子失衡和线粒体功能障碍导致 β-淀粉样蛋白（Aβ）异常聚集，是 AD 发病的关键因素。因此，我们设计了一种红细胞（RBC）膜封装的普鲁士蓝纳米颗粒（PB/RBC）的复合纳米系统。普鲁士蓝纳米颗粒（PBNP）可以螯合 Cu2+ 并减少活性氧（ROS）。红细胞膜是一种天然的长效循环载体。同时，通过近红外光照射，PBNPs优异的光热能力还可以暂时打开血脑屏障（BBB），增强PB/RBC跨血脑屏障的传输效率，解聚形成的Aβ沉积物，从而达到最佳的治疗效果。体外和体内研究表明，PB/RBC 可以抑制 Cu2+ 诱导的 Aβ 单体聚集，消除 Aβ 斑块的沉积，提高线粒体的质量，恢复小胶质细胞的吞噬功能，减轻 APP/PS1 小鼠的神经炎症，修复记忆损伤。总之，我们的生物膜伪装纳米递送系统通过抑制 Cu2+ 诱导的 Aβ 单体聚集、光热解聚 Aβ 原纤维和降低 ROS 水平，从而有效改善和治疗 AD，从而提供显着的神经保护。

更新日期：2024-09-13

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