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Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
Redox Biology ( IF 10.7 ) Pub Date : 2024-09-05 , DOI: 10.1016/j.redox.2024.103341 Anja Pammer 1 , Iva Klobučar 2 , Julia T Stadler 1 , Sabine Meissl 1 , Hansjörg Habisch 3 , Tobias Madl 4 , Saša Frank 5 , Vesna Degoricija 6 , Gunther Marsche 7
Redox Biology ( IF 10.7 ) Pub Date : 2024-09-05 , DOI: 10.1016/j.redox.2024.103341 Anja Pammer 1 , Iva Klobučar 2 , Julia T Stadler 1 , Sabine Meissl 1 , Hansjörg Habisch 3 , Tobias Madl 4 , Saša Frank 5 , Vesna Degoricija 6 , Gunther Marsche 7
Affiliation
Acute heart failure (AHF) is typified by inflammatory and oxidative stress responses, which are associated with unfavorable patient outcomes. Given the anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL), this study sought to examine the relationship between impaired HDL function and mortality in AHF patients. The complex interplay between various HDL-related biomarkers and clinical outcomes remains poorly understood.
中文翻译:
HDL 抗氧化和抗炎功能受损与急性心力衰竭患者死亡率增加有关
急性心力衰竭(AHF)的典型特征是炎症和氧化应激反应,这与不良的患者预后相关。鉴于高密度脂蛋白 (HDL) 的抗炎和抗氧化特性,本研究旨在探讨 HDL 功能受损与 AHF 患者死亡率之间的关系。各种 HDL 相关生物标志物与临床结果之间复杂的相互作用仍然知之甚少。
更新日期:2024-09-05
中文翻译:
HDL 抗氧化和抗炎功能受损与急性心力衰竭患者死亡率增加有关
急性心力衰竭(AHF)的典型特征是炎症和氧化应激反应,这与不良的患者预后相关。鉴于高密度脂蛋白 (HDL) 的抗炎和抗氧化特性,本研究旨在探讨 HDL 功能受损与 AHF 患者死亡率之间的关系。各种 HDL 相关生物标志物与临床结果之间复杂的相互作用仍然知之甚少。