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Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-10 , DOI: 10.1002/anie.202411707 Martin Wilkovitsch 1 , Walter Kuba 1 , Patrick Keppel 1 , Barbara Sohr 1 , Andreas Löffler 1 , Stefan Kronister 1 , Andres Fernandez Del Castillo 1 , Marion Goldeck 2 , Rastislav Dzijak 3 , Michal Rahm 3 , Milan Vrabel 3 , Dennis Svatunek 1 , Jonathan Carlson 4 , Hannes Mikula 5
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-10 , DOI: 10.1002/anie.202411707 Martin Wilkovitsch 1 , Walter Kuba 1 , Patrick Keppel 1 , Barbara Sohr 1 , Andreas Löffler 1 , Stefan Kronister 1 , Andres Fernandez Del Castillo 1 , Marion Goldeck 2 , Rastislav Dzijak 3 , Michal Rahm 3 , Milan Vrabel 3 , Dennis Svatunek 1 , Jonathan Carlson 4 , Hannes Mikula 5
Affiliation
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Highly reactive aryl-tetrazines are widely used for fast bioorthogonal ligation. However, their application in click-to-release chemistry has been impeded by significantly limited release efficiency. To address this challenge, we introduced hydroxyl functionalities to direct and accelerate post-click tautomerization, resulting in hydroxyaryl-tetrazines as bioorthogonal tools for highly efficient click-to-release of trans-cyclooctenes.
中文翻译：
将芳基-四嗪转化为生物正交剪刀，用于反式环辛烯的系统切割
高反应性芳基-四嗪广泛用于快速生物正交连接。然而，它们在点击释放化学中的应用受到明显限制的释放效率的阻碍。为了应对这一挑战，我们引入了羟基官能团来指导和加速点击后互变异构化，从而产生羟基芳基-四嗪作为高效点击释放反式环辛烯的生物正交工具。
更新日期：2024-09-10
中文翻译：
将芳基-四嗪转化为生物正交剪刀，用于反式环辛烯的系统切割
高反应性芳基-四嗪广泛用于快速生物正交连接。然而，它们在点击释放化学中的应用受到明显限制的释放效率的阻碍。为了应对这一挑战，我们引入了羟基官能团来指导和加速点击后互变异构化，从而产生羟基芳基-四嗪作为高效点击释放反式环辛烯的生物正交工具。
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