Stereoselective Synthesis of Oxetanes Catalyzed by an Engineered Halohydrin Dehalogenase,Angewandte Chemie International Edition

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Stereoselective Synthesis of Oxetanes Catalyzed by an Engineered Halohydrin Dehalogenase
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-09-09 , DOI: 10.1002/anie.202411326
Junkuan Li ₁ , Bo Yuan ₁ , Congcong Li ₁ , Zhouzhou Zhao ₁ , Jiaxin Guo ₁ , Pengpeng Zhang ₁ , Ge Qu ₂ , Zhoutong Sun ₃

Affiliation

Stereoselective protein engineering of halohydrin dehalogenases was conducted to access both R and S enantiomers starting from racemic oxetanes or γ-haloalcohols. The variants display high stereoselectivity and activity for both the dehalogenation of γ-haloalcohols and ring opening of oxetanes through kinetic resolution, yielding a broad range of functional chiral oxetanes and 1,3-disubstituted alcohols.

中文翻译：

由工程化卤醇脱卤酶催化的氧杂烷的立体选择性合成

对卤醇脱卤酶进行立体选择性蛋白质工程，以获得从外消旋氧杂烷或 γ-卤醇开始的 R 和 S 对映异构体。这些变体通过动力学分辨率对 γ-卤醇的脱卤和氧杂烷的开环反应都显示出高立体选择性和活性，从而产生广泛的功能性手性氧杂烷和 1,3-二取代醇。

更新日期：2024-09-09

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